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Bethesda (MD: National Institute of Diabetes and Digestive and Kidney Diseases (2012)

Kliewer KL, Ke JY, Lee HY et al (2015) Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice

That said, individuals with an MTHFR gene mutation confirmed by a blood test may benefit from methylated forms like methylcobalamin, which their bodies may process more effectively