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It is the leading cause of nephropathy and end-stage kidney disease, neuropathy, retinopathy and adult-onset blindness, non-traumatic amputation, and contributes greatly to heart disease and cardiovascular morbidity and mortality ( This meta-analysis showed that when initiated at the prediabetic stage, interventions with medications, specifically SGLT-2 inhibitors and GLP-1 receptor agonists, show promising evidence in delaying the progression of prediabetes into diabetes
Cold Spring Harb Perspect Biol 7 , a020412 (2015)
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