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Senescent fibroblasts and endothelial cells, through the secretion of SASPparticularly PDGF-Apromote an increase in myofibroblast numbers at wound sites, which positively affects wound healing [141]
"Sequence-structure analysis of FAD-containing proteins"
The pace of free radical generation, however, can often surpass the cellular production of glutathione (GSH), leading to a cascade of oxidative stress, chronic inflammation and tissue damage
Redox mechanisms are critical to this process and help moderate defense signaling and response, and GSH is one of the key components of the redox signaling process (Morris et al., 2014)
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