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There is also preclinical evidence that GLP-1RAs may directly modulate pain through reduction of central sensitization, suggesting the possibility of additional symptomatic improvement for IIH patients with headache (32)
Hypoglycemia Risks Hypoglycemia is rare in non-diabetics, but those combining GLP-1s with insulin or sulfonylureas face increased risk
However, the physiological mechanismprolonged gastric retention leading to increased intra-gastric pressureprovides a plausible explanation for why some patients may develop these symptoms
Central nervous system effects represent another area of concern
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