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The table lists reducing the size of each weekly increment, extending the interval between increases to four to eight weeks, temporarily returning to the previous level to test whether a recent increase caused the bloating, and exploring a microdose protocol with gentler escalation

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Gong et al., 2021

Endothelial dysfunction, which refers to an imbalance between various factors involved in relaxation and contraction, coagulation and anticoagulation, as well as inflammation and anti-inflammation, may play a substantial role in the pathogenesis of atherosclerosis and cardiovascular disease (94)