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In vivo time-course metabolomics analysis Standard and reagents Acetonitrile (Sigma-Aldrich), isopropanol (Sigma-Aldrich), methanol (Sigma-Aldrich), chloroform (Sigma-Aldrich), acetic acid (Sigma-Aldrich), formic acid (Sigma-Aldrich), methoxyamine hydrochloride (Sigma-Aldrich), MSTFA ( N -methyl- N -(trimethylsilyl) trifluoroacetamide

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B 12r appears orange-brown in solution, while B 12s appears bluish-green under natural daylight, and purple under artificial light

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