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however, it is also expressed in reactive astrocytes, endothelial cells, and vascular smooth muscle cells in AD brains (Gui et al., 2020)

Detoxification : Glutathione aids in the detoxification of harmful substances in the liver

the differential response of the glutathione and NADP redox states to oxidative challenge in glr1 and wild-type yeast and during reoxygenation in plants, the behaviour of NERNST closely mirrored that of the well-established E GSH sensor, roGFP2-Grx1, and particularly that of a free roGFP2, which can equilibrate with the glutathione redox couple via the action of endogenous glutaredoxins, and was opposite to that of the NAPstars

PD is an idiopathic neurodegenerative disorder characterized by heterogeneous pathophysiology with different molecular mechanisms across patients