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The intent with propensity-score matching was to identify control patients that were just as likely to have been prescribed GLP-1s as the treatment cohort based on a wide range of observed covariates, and it is reasonable to assume that such patients would be pursuing additional therapies over the study duration that would improve their weight and HbA1c as well
most patients with these diseases present in the first months of life with megaloblastic anemia, poor feeding, and, if not promptly diagnosed, various neurologic deficits, such as abnormal muscle tone and seizures
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Therefore, the growth disparity in 3D gels may stem from a distinct mechanism
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