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New England Journal of Medicine (2008) 359:11577-89

ATP generation on the other hand may be inadequate due to impaired substrate utilization due to insulin resistance and mitochondrial dysfunction [14]

If already deficient, some protocols call for 50,000 IU weekly under medical supervision until levels normalize

Although tirzepatide has no established direct mechanism for causing insomnia, several indirect pathways may explain why some patients experience sleep disturbances during treatment

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