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Nonetheless, it is unclear whether the protective effect of GLP-1R agonists on fat content stems from weight loss, which, among other things, increases insulin sensitivity and improves glycemia and lipid profile, or from direct activation of the hepatic GLP-1R
Weight loss also plays a major role
The severe infantile multisystem form manifest in the first 6 to 24 months of life with most afflicted infants demonstrating significant involvement before 1 year
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