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Real World (All-Comers): When you include everyone who started the trial (even those who stopped or missed doses), the weight loss was 13.4%
CNS actions GLP-1R signaling plays a critical role in the maintenance of glucose homeostasis as deletion of the GLP-1R in mice results in impaired glucose tolerance (Scrocchi et al., In addition to this direct control of beta cells, GLP-1R signaling plays a role in the control of glucose homeostasis by regulating the activity of neurons both in the peripheral and central nervous system
Regul Pept 2013
[1] [2] This leads to reduced calorie consumption and subsequent weight loss
