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Biosimilars One bright spot in drug pricing is the increased availability of biosimilars drugs that are highly similar to biologic medications
A retrospective study involving 431 patients with HCC found that patients with GS expression had poorer OS, more aggressive tumor features, and activation of tumor-promoting genes, compared to patients with GS-negative HCC, who showed better responses to sorafenib [242]
Notably, the pH responsiveness of CS further supports its microbiota-regulating effect: Its amino groups impart pH responsiveness, enabling environmentally triggered drug releaseit remains stable in the acidic gastric environment (pH 1.2) to avoid premature degradation, and only dissociates in the neutral-to-weakly alkaline colonic environment (pH 6.0-7.0) where it can directly interact with gut microbes and exert probiotic-enriching effects (187, 188)
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