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Risk assessment should extend beyond medication use alone and incorporate evaluation of gastrointestinal symptoms, treatment stage, dosage escalation status, underlying motility disorders, diabetes-related complications, and the urgency of the planned procedure
At this stage, weight loss often stabilizes into a steady pattern of one to two pounds per week, though some people experience natural plateaus lasting a week or two before dropping again
The SURMOUNT trials showed tirzepatide at 15 mg producing over 22% body weight loss on average, compared to roughly 15% for semaglutide 2.4 mg in the STEP trials
Safety Considerations and Who This Approach Applies To Semaglutide is not appropriate for everyone
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