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[6] [7] The medication has demonstrated cardiovascular benefits in clinical trials (SUSTAIN-6), reducing the risk of major adverse cardiovascular events in patients with established cardiovascular disease or high cardiovascular risk

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Most patients start at a low dose, work their way up, and then find the appropriate dosage throughout the rest of their journey

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[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

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Further, activation of the NLRP3 cascade promotes RF through RTEC pyroptosis (Hutton et al., 2016

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