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However, it has notable downsides: Cognitive side effects (brain fog, memory issues, difficulty concentrating) Can cause depression and mood instability Often leads to significant tingling sensations in the extremities Not as effective as newer weight-loss drugs Metformin Metformin is primarily used for type 2 diabetes but is sometimes prescribed off-label for weight loss due to its effects on insulin sensitivity and appetite
These results indicate that the elevated plasma GLP-1 levels contribute to the glucose-lowering effect of the activation of hepatic TR-mediated TH signaling in HFD-fed mice
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