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Risk factors for greater lean tissue loss likely include advanced age, rapid or large absolute weight loss, low dietary protein intake, sedentary lifestyle, and comorbid conditions such as chronic kidney disease or long-standing diabetes [15]
Retatrutide adds a third arm glucagon receptor agonism which preclinical and Phase 2 data suggest contributes additional hepatic lipid mobilization and energy expenditure effects not observed with mono- or dual-agonist compounds
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