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Nonetheless, the tirzepatide effect of delayed gastric emptying was found to significantly reduce oral contraceptive PK by ~ 60% and, thus, the drug label advises patients using oral hormonal contraceptives to switch to or add a non-oral contraceptive method when initiating tirzepatide and after each dose escalation

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Circulating levels peak in early adulthood and decline significantly with age dropping from roughly 200 ng/mL at age 20 to approximately 80 ng/mL by age 60