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For patients with contraindications to GLP-1 receptor agonists, numerous effective alternatives exist for managing type 2 diabetes and obesity

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Most peptides studied for weight loss do not function as direct fat burners. Instead, they: Reduce caloric intake Alter metabolic signalling Modify hormonal pathways Influence energy balance Fat loss is typically a downstream effect of sustained energy deficit combined with receptor-mediated metabolic changes

Reference Pizzorno J