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Oral formulations interact directly with your digestive system, and taking them right before lying down can affect absorption

This can cause memory loss, irreversible vision problems and damage to the nervous system

Lifestyle and dietary modifications form the cornerstone of initial management: Eat smaller, more frequent meals : Rather than three large meals, consider five to six smaller portions throughout the day to reduce gastric distension

Because of this learning curve, the fact that the technique can be untidy, and some theoretical concerns that methylene blue might be a carcinogen, this technique has not found favor in clinical practice