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The data are multiphasic presumably due to electrons flowing toward the flavin both from dithionite and reduced portions of the disulfide exchange relay that acquire electrons in the presence of dithionite
This means that the high level of heterogeneity was not possible to be attributed to any particular characteristic of the studies under investigation
Tandon et al., 2022) the authors evaluated the quality of the clinical trial included in the qualitative synthesis, based on 5 items assessing the randomization process, blinding, and the dropout rate (i.e., the patients lost to follow-up)
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