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Tirzepatide is a dual-receptor agonist that rewires appetite signaling from the gut to the brain

Conditions such as malnutrition, alcoholism, certain medical conditions (e.g., Crohns disease, celiac disease), or restrictive diets (e.g., veganism without adequate supplementation for *B12*) can lead to deficiencies in one or more of these crucial vitamins

Regular Exercise Physical activity can enhance the effects of B12 on energy levels and mood

Future research should prioritise long-term outcomes in high-risk groups, comparisons of physiological versus pharmacological dosages in healthy subjects, cost-effectiveness analyses, and adherence monitoring to inform clinical guidelines for the management and prevention of B12 deficiency