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Postmenopausal women experience a two- to three-fold increase in cardiometabolic risk, underscoring the need for targeted interventions. (Mauvais-Jarvis et al., 2017) Not All GLP-1 Agonists Are the Same Todays GLP-1 therapies vary in structure, receptor affinity, and clinical profile, and these nuances may matter for midlife women: Exenatide (Byetta, Bydureon): Derived from Gila monster venom peptide
during acute hyperglycemia, T1R2 transcript levels decrease in response to duodenal glucose infusion in healthy subjects, but increase in subjects with type 2 diabetes (134)
NICE-recommended licensed options include semaglutide (Wegovy) for adults meeting specific BMI and comorbidity criteria under NICE TA875, and orlistat available on prescription or over the counter
Refrain from using Semaglutide if you are planning to conceive
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