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In some dogs, this kind of explosive exercise can cause acute trauma, such as ligament ruptures and bone fractures

10.1007/10_2007_069 5 DuP.LiB.LiuX.YangL.RenN.LiY.et al (2022)

[note 16] [175] Toxicity In rodents and primates, sufficiently high doses of amphetamine cause dopaminergic neurotoxicity, or damage to dopamine neurons, which is characterized by dopamine terminal degeneration and reduced transporter and receptor function