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In general, dietary intake varies from 15 mg to 300 mg a day, depending on diet
The dose titration schedule starts at 2.5 mg and increases every 4 weeks through 5 mg, 7.5 mg, 10mg, and 12.5 mg before reaching the maintenance dose of 15 mg at around week 20
Then, you draw up your correct dose and administer it
A study that compared 24 obese patients with MC-4R deficiency to 80 healthy controls (40 obese and 40 lean) found that those with MC-4R mutations consumed significantly more high-fat meals
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