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If all appeals fail and you still need the medication, your options are paying cash for branded GLP-1s (Wegovy retail is around $1,350 per month, Zepbound around $1,060), using the manufacturer savings programs from Novo Nordisk or Eli Lilly, or pursuing compounded semaglutide or tirzepatide through a licensed telehealth provider
They are first released into the stomach acid where they help produce specific metabolites, and short chain fatty acids acetate, propionate, and butyrate
The long-term weight loss effect of GLP-1RAs has also been validated in a recent large-scale clinical trial, which reported a weight loss up to 20.9% after 72-week treatment of tirzepatide [22]
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