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Brandenburg C, Soghomonian JJ, Zhang K, Sulkaj I, Randolph B, Kachadoorian M, Blatt GJ
The peptide consists of 83 amino acids with a molecular weight of approximately 9.1 kDa, distinguished from native IGF-1 (70 amino acids) by two critical structural modifications: substitution of arginine for glutamic acid at position 3 and addition of a 13-amino acid extension at the N-terminus
The effect of GLP- 1 together with GIP on food intake, body weight, and locomotor activity was determined following intracerebroventricular (ICV) administration of GLP- 1 and/or GIP in mice
To test the effect of this putative pseudo-substrate on CDK11 activity, we performed kinase assays using wild-type CDK11 p58 -cyclin L2-SAP30BP and complexes harbouring a C-terminal deletion in CDK11, removing the putative pseudo-substrate segment (CDK11 C), the phospho-mimetic CDK11 S752E mutation, and the non-phosphorylatable CDK11 S752A mutation (CDK11B p110 residue numbering is used for consistency
