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In GLUTag cells, DCA-stimulated GLP-1 secretion was significantly inhibited by H-89, a PKA inhibitor, and/or ESI-09, inhibitors of EPAC1, and EPAC2, in the low-glucose (0.1 mM) state (Fig

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Four studies (131 participants) were pooled for the analysis of post-interventional VAT mass and no significant differences were observed with metformin (WMD: 163.8 g

Furthermore, typical side effects associated with the use of such drugs, including nausea and digestion problems, have resulted in an increased interest of consumers in products that do not cause discomfort and which are easily digestible, low on sugar and with controlled portions