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Canadas drug agency recognises several of these liraglutide, naltrexone-bupropion, orlistat, and semaglutide as effective at producing clinically significant weight loss over at least a year
Lower leptin signals energy deficit to the brain, which increases hunger and reduces metabolic rate to defend against further loss
For management: inject near bedtime (Strive recommended approach), eat small frequent meals, avoid greasy foods for 48 hours post-injection, and try ginger tea or supplements
Ultimately, implementation of immune-augmenting nutritional supplements within breast cancer care may require personalized approaches taking into consideration tumour subtype, underlying immunologic competency/deficiency, previous treatments received, microbiome profile and comorbid autoimmunity as well as multidisciplinary teamwork to translate promising immunobiologic signals into safe and empirically defined adjuncts to conventional anticancer immunity that are additive rather than counterproductive to patient health (197)
