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Topical GHK-Cu is generally well tolerated and has a low risk of side effects
Based on the phenomena directly observed in the OA model, the mechanisms verified in other chronic inflammatory/degenerative diseases [such as rheumatoid arthritis (RA)], and reasonable inferences based on the cross-linkages of molecular pathways, we propose a hypothetical framework, suggesting that the gut microbiota-ferroptosis axis ma contribute to the progression of OA and explore the therapeutic potential of synergistic intervention measures targeting this axis
McCommis et al., 2015
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