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The rationale is mechanistic rather than additive marketing language: a GHRH analog primes the pituitary while a ghrelin mimetic adds a separate, selective pulse, and researchers study whether the two together change the size or timing of growth hormone release

IGF-1 Axis & Anabolic Signaling Research The combined GH-stimulating effect of Modified GRF 1-29 and Ipamorelin produces consistent downstream elevation of IGF-1, the primary mediator of GH anabolic effects on skeletal muscle, bone, and connective tissue

However, the HPA axis will then respond to these heightened cortisol levels by decreasing the production of cortisol over time