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The researchers demonstrated that senescent cells depend on elevated FOXO4 to sequester p53 and avoid apoptosis, and designed a D-Retro-Inverso peptide to competitively block this interaction
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An important role of GSSG in the NFkB activating signal cascade is suggested by the facts that the potent NFk B inducer, tetradecanoyl phorbol acetate, increases intracellular GSSG levels and GSSG/GSH ratios
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