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pharmacological inhibition of HSP90 (such as geldanamycin) and/or genetic perturbation of HSP90-calcineurin signaling increase the efficacy of azoles and echinocandins against biofilms and reduce the survival of persisters in experimental studies (Cowen, 2009
7,9 The emergence and expansion of resistant clones are often driven by Darwinian evolutionary principles, whereby treatment selectively eliminates sensitive populations while allowing drug-tolerant persister (DTP) cells or preexisting resistant subclones to dominate
Foley, Bo Cai, Shyamal Peddada, Nigel J
Gy chn on bnh thiu chnh xc Vic ung biotin trc khi thc hin mt s xt nghim c th khin kt qu b sai lch, c bit l xt nghim chc nng tuyn gip
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