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In a study of colon cancer cells, COX-2 expression and PGE2 synthesis were upregulated by the IGF-2/IGF-1R autocrine pathway and IGF-1R blockade decreased COX-2 activity and inhibited tumor cell proliferation and promoted apoptosis (103)
2.3 Genetic instrument-based mediation analysis We conducted genetic causal analyses using the TwoSampleMR package
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