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Among GLP-1RAs, Semaglutide was the most cost-effective obesity medication [59] [60]
seven in absentia homolog 2 (SIAH2), a key regulator, together with hypoxia-inducible factor 1 alpha (HIF-1), of the cellular hypoxic responses under pathological conditions such as ischemia-reperfusion, whose association with NRF2 causes the degradation of NRF2 irrespective of its phosphorylation status [230]
5 Association of epilepsy with metabolic disorders in children 5.1 Congenital metabolic disorders and epilepsy in children In 7% of children, epilepsy is caused by a congenital metabolic disorder (112)
doi: 10.1007/s11357-025-01653-2, 21
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