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GIP receptor (GIPR) is also a type B G-protein-coupled receptor, which exists in various tissues such as pancreas, adipose tissue, gastric mucosa, heart, adrenal cortex, bone and brain
Clinical trials show probiotics produce modest weight loss of 0.5-2 kg, while FDA-approved medications like semaglutide and tirzepatide demonstrate 15-21% body weight reduction with robust clinical evidence
Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, et al
The critical element of a HBP is a Cys-X-X-Cys-His (CXXCH) heme-binding motif within the sequence, with X representing any amino acid residue [24]
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