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Meanwhile, cGAS-STING senses mitochondrial DNA (mtDNA) released from damaged mitochondria during ferroptosis and drives the production of type I interferons (IFN-I), thereby regulating expression of TfR1 and recruiting immune cells to intensify tissue injury (132, 133)
(2008) showed a significant reduction in colonic inflammation in a murine model, with improved histological scores
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Discontinuation for GLP-1s is not clinically supported at this time, as current literature suggests members need to stay on the medication indefinitely
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