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Ipamorelin, as a ghrelin receptor agonist, can simulate the secretion of ghrelin from the gastrointestinal tract, increasing patients' appetite and weight
Initially, when insulin resistance occurs, pancreatic bcells compensate by secreting more insulin to maintain normal glucose metabolism, but as the disease progresses, pancreatic b cell function deteriorates, insulin secretion significantly decreases, blood sugar cannot return to normal baseline levels, leading to metabolic disorders, including glucose and lipid abnormalities, and metabolic diseases such as T2DM (Warram et al., 1990
some people feel no appetite at all, while others notice strong hunger on certain days