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The screening identified quinoliniums as a promising scaffold, and 5-Amino-1MQ emerged as one of the most active compounds with an IC 50 of approximately 1.2 M under the biochemical assay conditions used
This metabolic shift creates a cascade of effects: stabilizing glucose levels that would otherwise fluctuate dramatically, reducing neuroinflammation that contributes to pain sensitivity, and providing ketones as an alternative fuel source for brain cells that may be experiencing energy deficits during migraine attacks
PMID 16685183
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