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In 2006, Bruno et al
At least 70 enzymes have been identified as requiring CoA or ACP derivatives for their function including the same critical thiamine-dependent enzymes described above, the pyruvate dehydrogenase complex (PDHc), 2-oxoglutarate (-ketoglutarate) dehydrogenase complex (OGDH), and branched-chain -ketoacid dehydrogenase complex (BCKD)
We acknowledged this as a limitation of the study and are aware that it may affect the interpretation of the results
PMID 13932735
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