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Typically, in cells expressing GHSR1a alone, pretreatment with SP-analog results in increased surface expression of GHSR1a and increased sensitivity

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Previous studies in myocardial ischemia have revealed that ischemia leads to a progressive loss of cholesterol from tissues and the sarcoplasmic and sarcoplasmic reticulum, accompanied by a significant increase in mitochondrial cholesterol content that is admixed explicitly to this membrane system [63]

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