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In chemotherapy-sensitive patients, Keap1 (Kelch-like ECH-associated protein 1) binds to NRF2 and mediates NRF2 ubiquitination via the Cul3-E3 ligase complex, promoting its degradation and maintaining NRF2 at low levels [32]

Their presence would indicate a problem with injection technique, preparation, or in rare cases, individual sensitivity that should prompt a review of the protocol and professional consultation

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The reduced dose provides ongoing support for skin health, immune function, and systemic inflammation control without the intensity of the optimization phase