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Standard Titration Protocol | Week | Dose | Purpose | |------|------|---------| | 1 through 4 | 0.25 mg once weekly | GI tolerability | | 5 through 8 | 0.5 mg once weekly | First therapeutic dose | | 9 through 12 | 1 mg once weekly (if needed) | Dose optimization | | 13 onward | 2 mg once weekly (if needed) | Maximum approved dose | The FDA label specifies that each dose escalation should occur after at least 4 weeks on the current dose 4
doi: 10.1016/s0140-6736(10)60307-8 114 GarberAHenryRRatnerRGarcia-HernandezPARodriguez-PattziHOlvera-AlvarezIet al
Unfortunately, severe side effects may persist longer
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