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Rotating to the abdomen every third day maintains therapeutic effect while giving local tissue a rest
Patients on immunosuppressants or blood thinners are also assessed carefully
Levels decline with age: MOTS-c is higher in younger people and drops over time, which is the core of its longevity rationale
Healthy user bias is very difficult to scrub out of observational studies, which compare people as they are treated in real life rather than assigning the drug at random
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