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References Neelakantan, H., Vance, V., et al

There are strong links between B-12 deficiency and depression

2001, AOD-9604 lost most of this fat-metabolism effect in mice that were genetically missing the beta-3 adrenergic receptor, suggesting that pathway carries part of the signal

This pathway allowed AOD-9604 to be marketed in the United States as a dietary supplement without the efficacy evidence required for a New Drug Application (NDA)

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