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Antipurinergic therapy for autisman in-depth review

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Ezeria, D., Takano, Y., Hanaoka, K., Urano, Y

3.3 Mitochondrial dysfunction and oxidative stress Chronic hyperglycemia in patients with T2DM leads to peripheral insulin resistance, whereas impaired insulin signaling pathways in the brains of patients with AD lead to brain insulin resistance, both of which are closely related to mitochondrial dysfunction and OS (Zhang et al., 2023)

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