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GPX7 and GPX8 also have cysteine as their active site and low glutathione peroxidase (GSH) activity, mainly due to the lack of domains bound to GSH
Together, these results, in alignment with in vivo and in vitro findings using Fer-1, demonstrate that inhibiting TEC ferroptosis protects against renal interstitial fibrosis through the inhibition of TGF-/Smad signaling
Zal T, Rytelewski M, Jacamo R, Zal MA, Shanmugasundaram M, Andreeff M
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