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For someone carrying significant excess weight, the cumulative load on this tissue over the course of a day is enormous, and it doesnt get adequate recovery time between bouts of activity
Either way, they're support, not a substitute
Metreleptin is a once daily subcutaneously administered leptin analogue approved by the FDA in 2014 for use in people with leptin deficiency or congenital/acquired lipodystrophy, with good clinical results in these conditions [86]
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