From a global epidemiologic perspective, it is associated with increased morbidity and mortality, healthcare costs, absenteeism, and presenteeism ( Evidence-based guidelines provide recommendations to healthcare professionals (HCP) for intense lifestyle interventions (ILI) with the aim of weight reduction and mitigation of cardiovascular risk ( Metabolic bariatric surgery (MBS) stands out as the most effective treatment for severe obesity, demonstrating significant and sustained weight loss while also improving various obesity-related health complications ( The development of safe and effective pharmacological agents for obesity has encountered significant challenges, marked by the emergence and subsequent decline of many medications due to adverse side effects, such as cardiovascular risk ( ) was approved in 2012

We work diligently to obtain and maintain third-party analytical reports and Certificates of Analysis for each batch covering identity, purity, quantitative assay, heavy metals (ICP-MS) and microbial counts (TAMC/TYMC), as part of our ongoing quality process
Four therapeutic areas illustrate this most starkly: oncology, cardiovascular disease, diabetes, and Alzheimer's disease
Niimura et al., The experimental value of zebrafish as an animal model for in vivo drug discovery has grown rapidly due to their ease of assessment, large clutch size, and ability to recapitulate human disease conditions (MacRae and Peterson, in vivo , demonstrating that otoprotective drug discovery in zebrafish translates to mammalian systems (Owens et al., 2011)