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Mechanistic studies indicated that these effects were not driven by acute insulinotropic activity, but by -cell preservation and enhanced glucose uptake
Use as a deliciously satisfying, nutritionally complete meal replacement or as a high-protein shake between meals
As indicated above, cellular uptake of thiamine occurs via the transporter encoded by the SLC19A3 gene
Therefore, if a new oral drug in development is intended to be co-administered with a GLP-1 agonist, we highly recommend conducting a healthy volunteer drug-drug interaction prior to Phase 3 trials to characterize the impact on the PK of the candidate new drug
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