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Lastly, niacinamide can be paired with glutathione, a tripeptide naturally present in the skin, known for its ability to modulate melanin synthesis by inhibiting tyrosinase and promoting a shift in melanogenesis toward the production of lighter pheomelanin
Here, they undergo incomplete, alternative oxidation pathways that generate massive amounts of free radicals and reactive oxygen species (ROS), further damaging the delicate mitochondrial membranes and the very enzymes required for energy production
10.1016/j.lwt.2012.01.019 21 ColognatoR.LaurenzaI.FontanaI.CoppedF.SicilianoG.CoeckeS.et al (2006)
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